The use of plasma therapy in patients with acne

“... Waking up in the morning, first I go to the mirror and see again three new pimples on my face. My morning started again with a high dose of cortisol and a bad mood. I quickly squeezed them out, wiped the blood dripping from my cheek, and applied a cotton pad soaked in calendula tincture. On the way to the university, I met the gazes of those around me, intently looking at my blue face after cleansing, took out a scarf, wrapped it around me and, lowering my head, moved on...”

This is what I heard from one of my patients. What could this mean? The fact that this disease affects the psycho-emotional state leads to asociality and complexness.

Acne is one of the most common dermatological diseases that occurs in our daily practice [1]. This disease affects approximately 85% of people aged 12-24 years [2, 3]. As a rule, acne occurs in patients during puberty, when, with an increase in the level of androgens, the sebaceous glands are activated, their hypertrophy occurs and, as a result, hyperproduction of sebum (sebum). It is considered a strong pro-inflammatory factor, providing the release of inflammatory mediators, which is associated with the development of severe forms of acne [4, 5]. Normalization of sebum production is a key point in prevention and treatment.

The main factors for the development of acne include the following:

1) Heredity – size, number, activity of the sebaceous gland and its sensitivity to sex hormones [6].

2) Impaired keratinization, when corneocytes do not exfoliate from the surface of the epithelium and, when accumulated, close the mouth of the excretory duct, creating optimal conditions for Propionibacterium acnes [7].

3) Hormonal factors: PCOS (polycystic ovary syndrome) and other diseases associated with hyperandrogenism [8].

By adhering to the treatment protocol and having a wide range of cosmetic procedures, we can speed up the regeneration process and, most importantly, reduce the signs of post-acne.

One of the main methods is the use of autologous platelet-rich plasma [9, 10].

Plasma therapy is a method of regenerative medicine that restores the integrity and function of tissue and cellular structures using autologous growth factors [10].

What is important for us when conducting plasma therapy?

- Bactericidal and bacteriostatic properties [11].

- Stimulation of local immunity [10, 12].

- Lack of leukocytes [13, 14, 15].

Clinical case analysis

Patient V. (born in 2001) Diagnosis: acne vulgaris, papulopustular form, moderate severity. In photo 1 we see the clinical picture of a patient with multiple papulopustular rashes on the face, stagnant spots, post-acne scars.

From the anamnesis we find out that this disease bothered the patient for 5 years, the rashes were localized on the back and chest.

He was treated with systemic antibiotics (azithromycin 250 mg per day for 8 weeks, after completing the course he was switched to systemic retinoids (acnetin) 16 mg per day for 2.5 months.

Diagnostics. The following tests were ordered:

CBC (complete blood count).

BAC (biochemical blood test) ALT, AST, total protein, bilirubin, cholesterol.

Glucose, insulin, ferritin.

Vitamin D

Analysis for Helicobacter pylori.

Cortisol.

Ultrasound – OBP, thyroid gland.

Based on the test results, the following treatment was prescribed:

1) Enterosgel – 1 s/l 2 times a day 1 hour before or after meals, 7 days.

2) Enterol – 1 capsule 2 times a day, 14 days.

3) Dermapro – 1 capsule 2 times a day, 30 days.

4) Omega 3-6 – 2000 mg per day with meals, 6 months.

5) Decrystol – 2000 mg per day with meals, 4 months.

6) Zinc picolinate (Solgar) – 1 tablet 2 times a day with meals, 3 months.

In the fourth month of treatment, the drug roacutane 10 mg per day for 6 months was prescribed to reduce sebum secretion and prevent relapse (photo 2 A-B).

During systemic treatment, the patient also underwent:

1) four procedures of 25% salicylic peeling, 1 procedure every 10 days with a gradual increase in the number of layers applied;

2) plasma therapy Endoret, one procedure every 3 weeks, 4 procedures.

Home Recommendations:

- limiting the consumption of dairy products and simple carbohydrates;

- maintaining healthy sleep from 23:00 to 07:00 to control cortisol levels;

- use of DMK cosmeceuticals;

- benzoyl peroxide 5%, topical retinoid Revitosin in the evening;

- benzoyl peroxide 5%, Acu moist, Herb mineral spray in the morning.

Adhering to this treatment regimen, we got a good result (photo 3 A-B). Rashes and congestive spots were eliminated, and the formation of post-acne scars was prevented. This has proven that plasma therapy is an effective method for the prevention and treatment of patients with acne.

Literature:

Dmitry Shavalyuk, general practitioner, cosmetologist (Ukraine)

Les Nouvelles Esthétiques Ukraine 1/2021