Regenerative medicine: a question of the future

Biology of skin regeneration

2025-11-06
Logo

The mechanisms of reparative regeneration are extremely complex, and the importance of this process is undeniable. Therefore, in this article we decided to understand how skin healing occurs.

Every year, new and new techniques appear in the field of cosmetology and aesthetic medicine, many of which injure the skin, disrupting the continuity and integrity of the epidermal barrier. Of course, an adequate assessment of the initial condition of the patient's skin and proper post-procedural care can minimize the negative consequences of damage, but practice shows that not all specialists pay tribute to this fact.

Stages of skin healing

Healing, or skin regeneration, is a complex process that occurs under the influence of various cellular components, components of the extracellular matrix and the cells themselves (keratinocytes, fibroblasts, endothelial cells, leukocytes and nerve cells). The phenomenon of regeneration involves several stages: the formation of a fibrin clot, inflammation, cell proliferation, tissue remodeling (reepithelialization), scarring.

Formation of a fibrin clot

Most skin wounds lead to blood loss due to damage to the blood vessels of the dermis. In this case, the formed clot serves as a temporary protective structure, preventing infection of damaged tissues, as well as forming a matrix within which cells can migrate for the reparative process.

Full version of the access article in Ukrainian

Read also