Peptide correction of hyperpigmentation

Factors that affect the change in skin color can be both external (affecting mainly the epidermis) and internal (affecting the dermal layer). Modern methods allow you to effectively deal with pigmented skin, but over time a black or brown spot appears again.) At this time, a lot of attention is paid to the appearance of the skin, so many cosmetic and pharmaceutical companies are focused on research that allows you to deal with hypermelanosis.

The formation of a pigment spot is a complex process, and in order to understand how to correct this problem, it is necessary to understand the process of melanin synthesis.

The color of human skin is formed in the epidermis, where melanocytes, which produce the pigment melanin, are located. After exposure to ultraviolet radiation on the skin, melanogenesis is enhanced by activation of the key enzyme of melanogenesis - tyrosinase.

Melanin synthesis begins with the catalysis of the substrates L-phenylalanine and L-tyrosine to form L-DOPA via phenylalanine hydroxylase, tyrosinase, and partially tyrosinase hydroxylase 1 (TH-1). The pathways are then divided into eumelanogenesis or pheomelanogenesis. Other melanogenic enzymes are TRP-2 (DCT) and TRP-1 for eumelanogenesis. No specific enzymes involved in pheomelanogenesis have yet been identified.

That is, ideally, for the correction of pigmentation, the doctor should direct his efforts simultaneously to all the key points of the formation of a pigment spot. And if previously the only option for melanogenesis was tyrosinase inhibition, modern technologies have expanded therapeutic possibilities.

Full version of the access article in Ukrainian

This article is part of the special project Skin pigmentation and its correction

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