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Skin quality

Science

Gastrointestinal (GI) pathology has a direct and indirect impact on skin condition, based on the concept of a bidirectional gut&ndash;skin axis. It is not just a concomitant symptom, but a complex link in the pathogenesis of many dermatological conditions.

<h2>Main pathogenetic mechanisms</h2>

Dysbiosis and increased permeability of the intestinal barrier: disruption of the qualitative and quantitative composition of the microbiota (dysbiosis) and the integrity of the intestinal epithelium leads to the translocation of bacterial metabolites (e.g., lipopolysaccharides &mdash; LPS) into the systemic bloodstream. This causes chronic low-level systemic inflammation, which is a trigger or aggravating factor for skin diseases.

Nutrient absorption disorders: chronic enteropathies, malabsorption (e.g., celiac disease, SNPK) lead to a deficiency of microelements and vitamins that are critical for skin health:

Zinc, iron, vitamins B, A, D, E &mdash; necessary for regeneration, antioxidant protection and immune homeostasis of the skin. Their deficiency manifests as xerosis, seborrheic dermatitis, impaired healing and increased sensitivity.

Immunological dysregulation: over 70% of immune cells are concentrated in gut-associated lymphoid tissue. Gastrointestinal disorders alter the balance of cytokines, which can provoke autoimmune and allergic reactions in the skin.

Full version of the access article <a href="https://pro.bhub.com.ua/cosmetology/vpliv-rozladiv-sistemi-travlennya-na-shkiru-vis-kishkivnikshkira">in Ukrainian</a>

The impact of digestive disorders on the skin: the gut-skin axis