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The article was translated into English using automatic translation. The editors are working on its improvement.

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Skin quality

Intense insolation during the summer season inevitably leads to the accumulation of structural changes in the skin, known as photoaging. Clinically, this is manifested by deterioration of texture, hyperkeratosis, deepening of wrinkles, as well as the appearance or increase of dyschromia and lentigo. At the molecular level, these processes correlate with chronic oxidative stress and a critical increase in the activity of matrix metalloproteinases (MMPs), in particular MMP-1 (collagenase). These enzymes cause the degradation of dermal collagen and elastin, forming the morphological basis for gravitational and structural ptosis.

Retinol (vitamin A), when transformed in the skin to biologically active retinoic acid, is able to modulate gene expression. Unlike most topical agents, retinoic acid acts through nuclear receptors (RAR and RXR), providing deep cellular restructuring.

Full version of the access article <a href="https://pro.bhub.com.ua/cosmetology/osinnie-vidnovlennya-shkiri-molekulyarni-mehanizmi-retinolu-v-korekcii-fotoushkodjen">in Ukrainian</a>

Autumn skin restoration: molecular mechanisms of retinol in photodamage correction