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The article was translated into English using automatic translation. The editors are working on its improvement.

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Age-related changes, such as wrinkles, decreased turgor, elasticity, deformation of the oval of the face, thinning of the skin and others, arise as a result of various physiological and pathological processes to which all structures of our body are exposed. Every day, the skin is exposed to many internal and external factors that accelerate the aging process. These include hormonal imbalance, chronic internal diseases, unhealthy lifestyle, constant stress, as well as excessive damaging effects of environmental factors. One of the most aggressive is ultraviolet irradiation. The capabilities of modern methods of non-hardware cosmetology make it possible to satisfy the needs of the most demanding clients who do not want to resort to plastic surgery and do not have time for a long rehabilitation period after any damaging procedures. Skin redermalization is one of the most effective modern methods of countering the processes of age-related and UV-induced aging. Restoring the skin from the inside involves introducing special preparations into the dermis that will have an antioxidant, anti-inflammatory effect on the cells and structure of the skin, and modulate local immunity. Why polynucleotides? Polynucleotides are natural DNA fractions that are capable of activating their own cellular repair due to direct stimulation of dermal cells (fibroblasts). The result is increased fibroblast regeneration and increased production of collagen and hyaluronic acid. The combination of PDRN with hyaluronic acid provides a lifting effect, antioxidant protection of skin cells, improvement of its tone and color, strengthening of the vascular wall, and immunomodulatory effect. To enhance the regeneration effect and prolong the result, the techniques can be combined with other anti-aging procedures (contour plastic surgery, peelings, laser treatment, thread placement, preparation and rehabilitation for plastic surgery). Polydeoxyribonucleotides of natural origin, isolated from salmon milk. And this is not accidental, because this biological material is most similar in functionality to human leukocytes. Thanks to high purification and combination with hyaluronic acid, TwAc preparations are most biocompatible with skin structures and always provide a pronounced and long-lasting effect of skin restoration and correction of various age-related changes. The main thing in choosing a drug is quality Years of experience of the Yuma Medical LP (UK) company in the research and production of redermalizant drugs allowed, using advanced technologies and evidence base, to develop new generation drugs based on PDRN in combination with hyaluronic acid (HA) of different concentrations and molecular weights for active and effective effects for various types and forms of aging, for different areas of exposure. A line of highly purified, multifunctional drugs with powerful and reliable evidence-based effectiveness has been developed. Among them:<ul><li> TwAc eyes is a mesotherapy drug for restoring and enhancing the regeneration and repair of the skin of delicate areas (orbital, perioral, neck, décolleté).</li><li> <a href="https://www.medhome.com.ua/twac">TwAc 2.0</a> - intradermal gel is intended for skin restoration with fine-wrinkled type of aging, for the prevention of the first signs of age-related changes during photo- and chronoaging, with frequent diets, after antibiotic and hormone replacement therapy, after pregnancy and lactation.</li></ul> <a href="https://www.medhome.com.ua/twac"><img alt="" src="https://pro.bhub.com.ua/cosmetology/upload/files/Twac_2_0_w2.png" style="width: 420px; height: 768px;" /></a><ul><li> <a href="https://www.medhome.com.ua/twac">TwAc 3.0</a> , which, thanks to the combination of PDRN and HA in the formula, causes a strengthening effect on the dermal matrix, restoring supporting function and maintaining tissue resistance. These indicators make it possible to use the drug for various types of aging, including deforming, after damaging cosmetic procedures, for the rapid restoration and replenishment of the functions of cells and structures of the dermal layers.</li></ul> <a href="https://www.medhome.com.ua/twac"><img alt="" src="https://pro.bhub.com.ua/cosmetology/upload/files/Twac_3_0_w2.png" style="width: 420px; height: 768px;" /></a> Main effects after the procedure:<ul><li> Correction of wrinkles of small and medium depth.</li><li> Correction of gravitational ptosis.</li><li> Restoring skin tone.</li><li> Restoring skin elasticity.</li><li> Improved complexion.</li><li> Narrowing of pores.</li><li> Reducing the manifestations of rosacea.</li><li> Prevention of age-related changes.</li><li> Regeneration of damaged tissues.</li></ul> Contraindications The drugs have only general contraindications associated with injection administration. They do not cause local or systemic toxicity, do not cause allergic reactions due to high-tech production and a high degree of purification of the components. Clinical Application Results of exposure using 1 syringe (3 ml) of the combined preparation TwAc 2.0. <img alt="" src="https://pro.bhub.com.ua/cosmetology/upload/files/image_2020-02-11_15-25-43%20%281%29.jpg" style="width: 800px; height: 582px;" /> Results of exposure using 2 x syringes (6 ml) of the combined preparation TwAc 3.0. <img alt="" src="https://pro.bhub.com.ua/cosmetology/upload/files/twacc.jpg" style="width: 650px; height: 650px;" /> Before the procedure <img alt="" src="https://pro.bhub.com.ua/cosmetology/upload/files/twac.jpg" style="width: 650px; height: 650px;" /> 1 week after the procedure

Advantages of drugs based on polynucleotides